Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial
Identifieur interne : 000191 ( Main/Exploration ); précédent : 000190; suivant : 000192Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial
Auteurs : Ting Fan Leung [Hong Kong] ; Anthony Pak-Yin Liu [Hong Kong] ; Fong Seng Lim [Singapour] ; Franck Thollot [France] ; Helen May Lin Oh [Singapour] ; Bee Wah Lee [Singapour] ; Lars Rombo [Suède] ; Ngiap Chuan Tan [Singapour] ; Roman Rouzier [France] ; Damien Friel [Belgique] ; Benoit De Muynck [Belgique] ; Stéphanie De Simoni [Belgique] ; Pemmaraju Suryakiran [Inde] ; Marjan Hezareh [Belgique] ; Nicolas Folschweiller [Belgique] ; Florence Thomas [Belgique] ; Frank Struyf [Belgique]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2015.
Abstract
This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9–14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6 (N = 358) or HPV-6/11/16/18(3D) at M0,2,6 (N = 358). The primary objective was non-inferiority/superiority of HPV-16/18 antibodies by ELISA for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) at M7 in the according-to-protocol immunogenicity cohort (ATP-I) and total vaccinated cohort, respectively. Secondary objectives included non-inferiority/superiority of HPV-16/18(2D) vs. HPV-6/11/16/18(3D) at M7, non-inferiority/superiority at M12, HPV-16/18 neutralizing antibodies, frequencies of T-cells/B-cells, reactogenicity and safety. Antibody responses at M7 for HPV-16/18(2D) were superior to those for HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) (lower limit of 95% confidence interval for geometric mean titer ratio (GMR) was >1): HPV-16/18(2D)/HPV-6/11/16/18(2D) GMRs were 1.69 [1.49–1.91] for anti-HPV-16 and 4.52 [3.97–5.13] for anti-HPV-18; HPV-16/18(2D)/HPV-6/11/16/18(3D) GMRs were 1.72 [1.54–1.93] for anti-HPV-16 and 3.22 [2.82–3.68] for anti-HPV-18; p = 0.0001 for all comparisons. Non-inferiority/superiority was also demonstrated at M12. Among initially seronegative girls in the ATP-I, neutralizing antibody titers were at least 1.8-fold higher for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) at M7 and M12. Frequencies of HPV-16/18-specific T-cells and B-cells were in similar ranges between groups. Reactogenicity and safety were in line with the known profile of each vaccine. In conclusion, superior HPV-16/18 antibody responses were elicited by 2 doses of the HPV-16/18 AS04-adjuvanted vaccine compared with 2 or 3 doses of the HPV-6/11/16/18 vaccine in girls (9–14 years).
Url:
DOI: 10.1080/21645515.2015.1050570
PubMed: 26062002
PubMed Central: 4514190
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000007
- to stream Pmc, to step Curation: 000007
- to stream Pmc, to step Checkpoint: 000027
- to stream Ncbi, to step Merge: 000479
- to stream Ncbi, to step Curation: 000479
- to stream Ncbi, to step Checkpoint: 000479
- to stream Main, to step Merge: 000189
- to stream Main, to step Curation: 000191
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial</title><author><name sortKey="Leung, Ting Fan" sort="Leung, Ting Fan" uniqKey="Leung T" first="Ting Fan" last="Leung">Ting Fan Leung</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Paediatrics; The Chinese University of Hong Kong</institution>; Shatin,<country>Hong Kong</country></nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0014">These authors equally contributed to the work.</nlm:aff></affiliation></author><author><name sortKey="Liu, Anthony Pak Yin" sort="Liu, Anthony Pak Yin" uniqKey="Liu A" first="Anthony Pak-Yin" last="Liu">Anthony Pak-Yin Liu</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Paediatrics and Adolescent Medicine; Li Ka Shing Faculty of Medicine; The University of Hong Kong</institution>;<country>Hong Kong</country></nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0014">These authors equally contributed to the work.</nlm:aff></affiliation></author><author><name sortKey="Lim, Fong Seng" sort="Lim, Fong Seng" uniqKey="Lim F" first="Fong Seng" last="Lim">Fong Seng Lim</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>National Healthcare Group Polyclinics and National University of Singapore</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thollot, Franck" sort="Thollot, Franck" uniqKey="Thollot F" first="Franck" last="Thollot">Franck Thollot</name><affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Association Française de Pédiatrie Ambulatoire (AFPA); Essey Les Nancy</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Helen May Lin" sort="Oh, Helen May Lin" uniqKey="Oh H" first="Helen May Lin" last="Oh">Helen May Lin Oh</name><affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Division of Infectious Disease; Changi General Hospital</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Bee Wah" sort="Lee, Bee Wah" uniqKey="Lee B" first="Bee Wah" last="Lee">Bee Wah Lee</name><affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Mount Elizabeth Medical Center and National University of Singapore</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rombo, Lars" sort="Rombo, Lars" uniqKey="Rombo L" first="Lars" last="Rombo">Lars Rombo</name><affiliation wicri:level="1"><nlm:aff id="af0007"><institution>Centre for Clinical Research; Sormland County Council; Uppsala University and Karolinska Institute</institution>; Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Ngiap Chuan" sort="Tan, Ngiap Chuan" uniqKey="Tan N" first="Ngiap Chuan" last="Tan">Ngiap Chuan Tan</name><affiliation wicri:level="1"><nlm:aff id="af0008"><institution>SingHealth Polyclinics and DUKE-NUS Graduate Medical School</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rouzier, Roman" sort="Rouzier, Roman" uniqKey="Rouzier R" first="Roman" last="Rouzier">Roman Rouzier</name><affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Institut Curie</institution>; Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friel, Damien" sort="Friel, Damien" uniqKey="Friel D" first="Damien" last="Friel">Damien Friel</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Muynck, Benoit" sort="De Muynck, Benoit" uniqKey="De Muynck B" first="Benoit" last="De Muynck">Benoit De Muynck</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Simoni, Stephanie" sort="De Simoni, Stephanie" uniqKey="De Simoni S" first="Stéphanie" last="De Simoni">Stéphanie De Simoni</name><affiliation wicri:level="1"><nlm:aff id="af0011"><institution>GSK Vaccines</institution>; Rixensart,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suryakiran, Pemmaraju" sort="Suryakiran, Pemmaraju" uniqKey="Suryakiran P" first="Pemmaraju" last="Suryakiran">Pemmaraju Suryakiran</name><affiliation wicri:level="1"><nlm:aff id="af0012"><institution>GlaxoSmithKline Pharmaceuticals India Ltd.</institution>; Bangalore,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hezareh, Marjan" sort="Hezareh, Marjan" uniqKey="Hezareh M" first="Marjan" last="Hezareh">Marjan Hezareh</name><affiliation wicri:level="1"><nlm:aff id="af0013"><institution>Chiltern International for GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Folschweiller, Nicolas" sort="Folschweiller, Nicolas" uniqKey="Folschweiller N" first="Nicolas" last="Folschweiller">Nicolas Folschweiller</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Florence" sort="Thomas, Florence" uniqKey="Thomas F" first="Florence" last="Thomas">Florence Thomas</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26062002</idno><idno type="pmc">4514190</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514190</idno><idno type="RBID">PMC:4514190</idno><idno type="doi">10.1080/21645515.2015.1050570</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000007</idno><idno type="wicri:Area/Pmc/Curation">000007</idno><idno type="wicri:Area/Pmc/Checkpoint">000027</idno><idno type="wicri:Area/Ncbi/Merge">000479</idno><idno type="wicri:Area/Ncbi/Curation">000479</idno><idno type="wicri:Area/Ncbi/Checkpoint">000479</idno><idno type="wicri:doubleKey">2164-5515:2015:Leung T:comparative:immunogenicity:and</idno><idno type="wicri:Area/Main/Merge">000189</idno><idno type="wicri:Area/Main/Curation">000191</idno><idno type="wicri:Area/Main/Exploration">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial</title><author><name sortKey="Leung, Ting Fan" sort="Leung, Ting Fan" uniqKey="Leung T" first="Ting Fan" last="Leung">Ting Fan Leung</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Paediatrics; The Chinese University of Hong Kong</institution>; Shatin,<country>Hong Kong</country></nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0014">These authors equally contributed to the work.</nlm:aff></affiliation></author><author><name sortKey="Liu, Anthony Pak Yin" sort="Liu, Anthony Pak Yin" uniqKey="Liu A" first="Anthony Pak-Yin" last="Liu">Anthony Pak-Yin Liu</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Paediatrics and Adolescent Medicine; Li Ka Shing Faculty of Medicine; The University of Hong Kong</institution>;<country>Hong Kong</country></nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0014">These authors equally contributed to the work.</nlm:aff></affiliation></author><author><name sortKey="Lim, Fong Seng" sort="Lim, Fong Seng" uniqKey="Lim F" first="Fong Seng" last="Lim">Fong Seng Lim</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>National Healthcare Group Polyclinics and National University of Singapore</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thollot, Franck" sort="Thollot, Franck" uniqKey="Thollot F" first="Franck" last="Thollot">Franck Thollot</name><affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Association Française de Pédiatrie Ambulatoire (AFPA); Essey Les Nancy</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Helen May Lin" sort="Oh, Helen May Lin" uniqKey="Oh H" first="Helen May Lin" last="Oh">Helen May Lin Oh</name><affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Division of Infectious Disease; Changi General Hospital</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Bee Wah" sort="Lee, Bee Wah" uniqKey="Lee B" first="Bee Wah" last="Lee">Bee Wah Lee</name><affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Mount Elizabeth Medical Center and National University of Singapore</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rombo, Lars" sort="Rombo, Lars" uniqKey="Rombo L" first="Lars" last="Rombo">Lars Rombo</name><affiliation wicri:level="1"><nlm:aff id="af0007"><institution>Centre for Clinical Research; Sormland County Council; Uppsala University and Karolinska Institute</institution>; Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Ngiap Chuan" sort="Tan, Ngiap Chuan" uniqKey="Tan N" first="Ngiap Chuan" last="Tan">Ngiap Chuan Tan</name><affiliation wicri:level="1"><nlm:aff id="af0008"><institution>SingHealth Polyclinics and DUKE-NUS Graduate Medical School</institution>;<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rouzier, Roman" sort="Rouzier, Roman" uniqKey="Rouzier R" first="Roman" last="Rouzier">Roman Rouzier</name><affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Institut Curie</institution>; Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Friel, Damien" sort="Friel, Damien" uniqKey="Friel D" first="Damien" last="Friel">Damien Friel</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Muynck, Benoit" sort="De Muynck, Benoit" uniqKey="De Muynck B" first="Benoit" last="De Muynck">Benoit De Muynck</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Simoni, Stephanie" sort="De Simoni, Stephanie" uniqKey="De Simoni S" first="Stéphanie" last="De Simoni">Stéphanie De Simoni</name><affiliation wicri:level="1"><nlm:aff id="af0011"><institution>GSK Vaccines</institution>; Rixensart,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suryakiran, Pemmaraju" sort="Suryakiran, Pemmaraju" uniqKey="Suryakiran P" first="Pemmaraju" last="Suryakiran">Pemmaraju Suryakiran</name><affiliation wicri:level="1"><nlm:aff id="af0012"><institution>GlaxoSmithKline Pharmaceuticals India Ltd.</institution>; Bangalore,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hezareh, Marjan" sort="Hezareh, Marjan" uniqKey="Hezareh M" first="Marjan" last="Hezareh">Marjan Hezareh</name><affiliation wicri:level="1"><nlm:aff id="af0013"><institution>Chiltern International for GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Folschweiller, Nicolas" sort="Folschweiller, Nicolas" uniqKey="Folschweiller N" first="Nicolas" last="Folschweiller">Nicolas Folschweiller</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Florence" sort="Thomas, Florence" uniqKey="Thomas F" first="Florence" last="Thomas">Florence Thomas</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>GSK Vaccines</institution>; Wavre,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9–14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6 (N = 358) or HPV-6/11/16/18(3D) at M0,2,6 (N = 358). The primary objective was non-inferiority/superiority of HPV-16/18 antibodies by ELISA for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) at M7 in the according-to-protocol immunogenicity cohort (ATP-I) and total vaccinated cohort, respectively. Secondary objectives included non-inferiority/superiority of HPV-16/18(2D) vs. HPV-6/11/16/18(3D) at M7, non-inferiority/superiority at M12, HPV-16/18 neutralizing antibodies, frequencies of T-cells/B-cells, reactogenicity and safety. Antibody responses at M7 for HPV-16/18(2D) were superior to those for HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) (lower limit of 95% confidence interval for geometric mean titer ratio (GMR) was >1): HPV-16/18(2D)/HPV-6/11/16/18(2D) GMRs were 1.69 [1.49–1.91] for anti-HPV-16 and 4.52 [3.97–5.13] for anti-HPV-18; HPV-16/18(2D)/HPV-6/11/16/18(3D) GMRs were 1.72 [1.54–1.93] for anti-HPV-16 and 3.22 [2.82–3.68] for anti-HPV-18; p = 0.0001 for all comparisons. Non-inferiority/superiority was also demonstrated at M12. Among initially seronegative girls in the ATP-I, neutralizing antibody titers were at least 1.8-fold higher for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) at M7 and M12. Frequencies of HPV-16/18-specific T-cells and B-cells were in similar ranges between groups. Reactogenicity and safety were in line with the known profile of each vaccine. In conclusion, superior HPV-16/18 antibody responses were elicited by 2 doses of the HPV-16/18 AS04-adjuvanted vaccine compared with 2 or 3 doses of the HPV-6/11/16/18 vaccine in girls (9–14 years).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Einstein, Mh" uniqKey="Einstein M">MH Einstein</name></author><author><name sortKey="Baron, M" uniqKey="Baron M">M Baron</name></author><author><name sortKey="Levin, Mj" uniqKey="Levin M">MJ Levin</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author><author><name sortKey="Edwards, Rp" uniqKey="Edwards R">RP Edwards</name></author><author><name sortKey="Zepp, F" uniqKey="Zepp F">F Zepp</name></author><author><name sortKey="Carletti, I" uniqKey="Carletti I">I Carletti</name></author><author><name sortKey="Dessy, Fj" uniqKey="Dessy F">FJ Dessy</name></author><author><name sortKey="Trofa, Af" uniqKey="Trofa A">AF Trofa</name></author><author><name sortKey="Schuind, A" uniqKey="Schuind A">A Schuind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Sanjose, S" uniqKey="De Sanjose S">S de Sanjosé</name></author><author><name sortKey="Quint, Wg" uniqKey="Quint W">WG Quint</name></author><author><name sortKey="Alemany, L" uniqKey="Alemany L">L Alemany</name></author><author><name sortKey="Geraets, Dt" uniqKey="Geraets D">DT Geraets</name></author><author><name sortKey="Klaustermeier, Je" uniqKey="Klaustermeier J">JE Klaustermeier</name></author><author><name sortKey="Lloveras, B" uniqKey="Lloveras B">B Lloveras</name></author><author><name sortKey="Tous, S" uniqKey="Tous S">S Tous</name></author><author><name sortKey="Felix, A" uniqKey="Felix A">A Felix</name></author><author><name sortKey="Bravo, Le" uniqKey="Bravo L">LE Bravo</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Franceschi, S" uniqKey="Franceschi S">S Franceschi</name></author><author><name sortKey="Howell Jones, R" uniqKey="Howell Jones R">R Howell-Jones</name></author><author><name sortKey="Snijders, Pj" uniqKey="Snijders P">PJ Snijders</name></author><author><name sortKey="Clifford, Gm" uniqKey="Clifford G">GM Clifford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruni, L" uniqKey="Bruni L">L Bruni</name></author><author><name sortKey="Barrionuevo Rosas, L" uniqKey="Barrionuevo Rosas L">L Barrionuevo-Rosas</name></author><author><name sortKey="Serrano, B" uniqKey="Serrano B">B Serrano</name></author><author><name sortKey="Brotons, M" uniqKey="Brotons M">M Brotons</name></author><author><name sortKey="Cosano, R" uniqKey="Cosano R">R Cosano</name></author><author><name sortKey="Mu Oz, J" uniqKey="Mu Oz J">J Muñoz</name></author><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="De Sanjose, S" uniqKey="De Sanjose S">S de Sanjosé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, C" uniqKey="Pedersen C">C Pedersen</name></author><author><name sortKey="Petaja, T" uniqKey="Petaja T">T Petaja</name></author><author><name sortKey="Strauss, G" uniqKey="Strauss G">G Strauss</name></author><author><name sortKey="Rumke, Hc" uniqKey="Rumke H">HC Rumke</name></author><author><name sortKey="Poder, A" uniqKey="Poder A">A Poder</name></author><author><name sortKey="Richardus, Jh" uniqKey="Richardus J">JH Richardus</name></author><author><name sortKey="Spiessens, B" uniqKey="Spiessens B">B Spiessens</name></author><author><name sortKey="Descamps, D" uniqKey="Descamps D">D Descamps</name></author><author><name sortKey="Hardt, K" uniqKey="Hardt K">K Hardt</name></author><author><name sortKey="Lehtinen, M" uniqKey="Lehtinen M">M Lehtinen</name></author><author><name sortKey="Dubin, G" uniqKey="Dubin G">G Dubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Block, Sl" uniqKey="Block S">SL Block</name></author><author><name sortKey="Nolan, T" uniqKey="Nolan T">T Nolan</name></author><author><name sortKey="Sattler, C" uniqKey="Sattler C">C Sattler</name></author><author><name sortKey="Barr, E" uniqKey="Barr E">E Barr</name></author><author><name sortKey="Giacoletti, Ke" uniqKey="Giacoletti K">KE Giacoletti</name></author><author><name sortKey="Marchant, Cd" uniqKey="Marchant C">CD Marchant</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author><author><name sortKey="Rusche, Sa" uniqKey="Rusche S">SA Rusche</name></author><author><name sortKey="Lukac, S" uniqKey="Lukac S">S Lukac</name></author><author><name sortKey="Bryan, Jt" uniqKey="Bryan J">JT Bryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, Dm" uniqKey="Harper D">DM Harper</name></author><author><name sortKey="Franco, El" uniqKey="Franco E">EL Franco</name></author><author><name sortKey="Wheeler, C" uniqKey="Wheeler C">C Wheeler</name></author><author><name sortKey="Ferris, Dg" uniqKey="Ferris D">DG Ferris</name></author><author><name sortKey="Jenkins, D" uniqKey="Jenkins D">D Jenkins</name></author><author><name sortKey="Schuind, A" uniqKey="Schuind A">A Schuind</name></author><author><name sortKey="Zahaf, T" uniqKey="Zahaf T">T Zahaf</name></author><author><name sortKey="Innis, B" uniqKey="Innis B">B Innis</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="De Carvalho, Ns" uniqKey="De Carvalho N">NS De Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, Dm" uniqKey="Harper D">DM Harper</name></author><author><name sortKey="Franco, El" uniqKey="Franco E">EL Franco</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Moscicki, Ab" uniqKey="Moscicki A">AB Moscicki</name></author><author><name sortKey="Romanowski, B" uniqKey="Romanowski B">B Romanowski</name></author><author><name sortKey="Roteli Martins, Cm" uniqKey="Roteli Martins C">CM Roteli-Martins</name></author><author><name sortKey="Jenkins, D" uniqKey="Jenkins D">D Jenkins</name></author><author><name sortKey="Schuind, A" uniqKey="Schuind A">A Schuind</name></author><author><name sortKey="Costa Clemens, Sa" uniqKey="Costa Clemens S">SA Costa Clemens</name></author><author><name sortKey="Dubin, G" uniqKey="Dubin G">G Dubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J Paavonen</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="Salmeron, J" uniqKey="Salmeron J">J Salmeron</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Chow, Sn" uniqKey="Chow S">SN Chow</name></author><author><name sortKey="Apter, D" uniqKey="Apter D">D Apter</name></author><author><name sortKey="Kitchener, H" uniqKey="Kitchener H">H Kitchener</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author><author><name sortKey="Teixeira, Jc" uniqKey="Teixeira J">JC Teixeira</name></author><author><name sortKey="Skinner, Sr" uniqKey="Skinner S">SR Skinner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehtinen, M" uniqKey="Lehtinen M">M Lehtinen</name></author><author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J Paavonen</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Jaisamrarn, U" uniqKey="Jaisamrarn U">U Jaisamrarn</name></author><author><name sortKey="Garland, Sm" uniqKey="Garland S">SM Garland</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author><author><name sortKey="Skinner, Sr" uniqKey="Skinner S">SR Skinner</name></author><author><name sortKey="Apter, D" uniqKey="Apter D">D Apter</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="Salmeron, J" uniqKey="Salmeron J">J Salmeron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author><author><name sortKey="Garland, Sm" uniqKey="Garland S">SM Garland</name></author><author><name sortKey="Szarewski, A" uniqKey="Szarewski A">A Szarewski</name></author><author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J Paavonen</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="Salmeron, J" uniqKey="Salmeron J">J Salmeron</name></author><author><name sortKey="Chow, Sn" uniqKey="Chow S">SN Chow</name></author><author><name sortKey="Apter, D" uniqKey="Apter D">D Apter</name></author><author><name sortKey="Kitchener, H" uniqKey="Kitchener H">H Kitchener</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ault, Ka" uniqKey="Ault K">KA Ault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanowski, B" uniqKey="Romanowski B">B Romanowski</name></author><author><name sortKey="Schwarz, Tf" uniqKey="Schwarz T">TF Schwarz</name></author><author><name sortKey="Ferguson, Lm" uniqKey="Ferguson L">LM Ferguson</name></author><author><name sortKey="Peters, K" uniqKey="Peters K">K Peters</name></author><author><name sortKey="Dionne, M" uniqKey="Dionne M">M Dionne</name></author><author><name sortKey="Schulze, K" uniqKey="Schulze K">K Schulze</name></author><author><name sortKey="Ramjattan, B" uniqKey="Ramjattan B">B Ramjattan</name></author><author><name sortKey="Hillemanns, P" uniqKey="Hillemanns P">P Hillemanns</name></author><author><name sortKey="Catteau, G" uniqKey="Catteau G">G Catteau</name></author><author><name sortKey="Dobbelaere, K" uniqKey="Dobbelaere K">K Dobbelaere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puthanakit, T" uniqKey="Puthanakit T">T Puthanakit</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Tang, R" uniqKey="Tang R">R Tang</name></author><author><name sortKey="Schwarz, T" uniqKey="Schwarz T">T Schwarz</name></author><author><name sortKey="Esposito, S" uniqKey="Esposito S">S Esposito</name></author><author><name sortKey="Frenette, L" uniqKey="Frenette L">L Frenette</name></author><author><name sortKey="Mcneil, S" uniqKey="Mcneil S">S McNeil</name></author><author><name sortKey="Rheault, P" uniqKey="Rheault P">P Rheault</name></author><author><name sortKey="Horn, M" uniqKey="Horn M">M Horn</name></author><author><name sortKey="Klar, M" uniqKey="Klar M">M Klar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanowski, B" uniqKey="Romanowski B">B Romanowski</name></author><author><name sortKey="Schwarz, Tf" uniqKey="Schwarz T">TF Schwarz</name></author><author><name sortKey="Ferguson, Lm" uniqKey="Ferguson L">LM Ferguson</name></author><author><name sortKey="Ferguson, M" uniqKey="Ferguson M">M Ferguson</name></author><author><name sortKey="Peters, K" uniqKey="Peters K">K Peters</name></author><author><name sortKey="Dionne, M" uniqKey="Dionne M">M Dionne</name></author><author><name sortKey="Schulze, K" uniqKey="Schulze K">K Schulze</name></author><author><name sortKey="Ramjattan, B" uniqKey="Ramjattan B">B Ramjattan</name></author><author><name sortKey="Hillemanns, P" uniqKey="Hillemanns P">P Hillemanns</name></author><author><name sortKey="Behre, U" uniqKey="Behre U">U Behre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dobson, Sr" uniqKey="Dobson S">SR Dobson</name></author><author><name sortKey="Mcneil, S" uniqKey="Mcneil S">S McNeil</name></author><author><name sortKey="Dionne, M" uniqKey="Dionne M">M Dionne</name></author><author><name sortKey="Dawar, M" uniqKey="Dawar M">M Dawar</name></author><author><name sortKey="Ogilvie, G" uniqKey="Ogilvie G">G Ogilvie</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M Krajden</name></author><author><name sortKey="Sauvageau, C" uniqKey="Sauvageau C">C Sauvageau</name></author><author><name sortKey="Scheifele, Dw" uniqKey="Scheifele D">DW Scheifele</name></author><author><name sortKey="Kollmann, Tr" uniqKey="Kollmann T">TR Kollmann</name></author><author><name sortKey="Halperin, Sa" uniqKey="Halperin S">SA Halperin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J Paavonen</name></author><author><name sortKey="Jenkins, D" uniqKey="Jenkins D">D Jenkins</name></author><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="Salmeron, J" uniqKey="Salmeron J">J Salmeron</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Chow, Sn" uniqKey="Chow S">SN Chow</name></author><author><name sortKey="Apter, Dl" uniqKey="Apter D">DL Apter</name></author><author><name sortKey="Kitchener, Hc" uniqKey="Kitchener H">HC Kitchener</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsagué</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, Dm" uniqKey="Harper D">DM Harper</name></author><author><name sortKey="Verdenius, I" uniqKey="Verdenius I">I Verdenius</name></author><author><name sortKey="Ratnaraj, F" uniqKey="Ratnaraj F">F Ratnaraj</name></author><author><name sortKey="Arey, Am" uniqKey="Arey A">AM Arey</name></author><author><name sortKey="Rosemergey, B" uniqKey="Rosemergey B">B Rosemergey</name></author><author><name sortKey="Malnar, Gj" uniqKey="Malnar G">GJ Malnar</name></author><author><name sortKey="Wall, J" uniqKey="Wall J">J Wall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markowitz, Le" uniqKey="Markowitz L">LE Markowitz</name></author><author><name sortKey="Tsu, V" uniqKey="Tsu V">V Tsu</name></author><author><name sortKey="Deeks, Sl" uniqKey="Deeks S">SL Deeks</name></author><author><name sortKey="Cubie, H" uniqKey="Cubie H">H Cubie</name></author><author><name sortKey="Wang, Sa" uniqKey="Wang S">SA Wang</name></author><author><name sortKey="Vicari, As" uniqKey="Vicari A">AS Vicari</name></author><author><name sortKey="Brotherton, Jm" uniqKey="Brotherton J">JM Brotherton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hopkins, Tg" uniqKey="Hopkins T">TG Hopkins</name></author><author><name sortKey="Wood, N" uniqKey="Wood N">N Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harper, Dm" uniqKey="Harper D">DM Harper</name></author><author><name sortKey="Verdenius, I" uniqKey="Verdenius I">I Verdenius</name></author><author><name sortKey="Harris, Gd" uniqKey="Harris G">GD Harris</name></author><author><name sortKey="Barnett, Al" uniqKey="Barnett A">AL Barnett</name></author><author><name sortKey="Rosemergey, Be" uniqKey="Rosemergey B">BE Rosemergey</name></author><author><name sortKey="Arey, Am" uniqKey="Arey A">AM Arey</name></author><author><name sortKey="Wall, J" uniqKey="Wall J">J Wall</name></author><author><name sortKey="Malnar, Gj" uniqKey="Malnar G">GJ Malnar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Einstein, Mh" uniqKey="Einstein M">MH Einstein</name></author><author><name sortKey="Takacs, P" uniqKey="Takacs P">P Takacs</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author><author><name sortKey="Sperling, Rs" uniqKey="Sperling R">RS Sperling</name></author><author><name sortKey="Chakhtoura, N" uniqKey="Chakhtoura N">N Chakhtoura</name></author><author><name sortKey="Blatter, Mm" uniqKey="Blatter M">MM Blatter</name></author><author><name sortKey="Lalezari, J" uniqKey="Lalezari J">J Lalezari</name></author><author><name sortKey="David, Mp" uniqKey="David M">MP David</name></author><author><name sortKey="Lin, L" uniqKey="Lin L">L Lin</name></author><author><name sortKey="Struyf, F" uniqKey="Struyf F">F Struyf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Draper, E" uniqKey="Draper E">E Draper</name></author><author><name sortKey="Bissett, Sl" uniqKey="Bissett S">SL Bissett</name></author><author><name sortKey="Howell Jones, R" uniqKey="Howell Jones R">R Howell-Jones</name></author><author><name sortKey="Waight, P" uniqKey="Waight P">P Waight</name></author><author><name sortKey="Soldan, K" uniqKey="Soldan K">K Soldan</name></author><author><name sortKey="Jit, M" uniqKey="Jit M">M Jit</name></author><author><name sortKey="Andrews, N" uniqKey="Andrews N">N Andrews</name></author><author><name sortKey="Miller, E" uniqKey="Miller E">E Miller</name></author><author><name sortKey="Beddows, S" uniqKey="Beddows S">S Beddows</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toft, L" uniqKey="Toft L">L Toft</name></author><author><name sortKey="Storgaard, M" uniqKey="Storgaard M">M Storgaard</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author><author><name sortKey="Sehr, P" uniqKey="Sehr P">P Sehr</name></author><author><name sortKey="Bonde, J" uniqKey="Bonde J">J Bonde</name></author><author><name sortKey="Tolstrup, M" uniqKey="Tolstrup M">M Tolstrup</name></author><author><name sortKey=" Stergaard, L" uniqKey=" Stergaard L">L Østergaard</name></author><author><name sortKey="S Gaard, Os" uniqKey="S Gaard O">OS Søgaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barzon, L" uniqKey="Barzon L">L Barzon</name></author><author><name sortKey="Squarzon, L" uniqKey="Squarzon L">L Squarzon</name></author><author><name sortKey="Masiero, S" uniqKey="Masiero S">S Masiero</name></author><author><name sortKey="Pacenti, M" uniqKey="Pacenti M">M Pacenti</name></author><author><name sortKey="Marcati, G" uniqKey="Marcati G">G Marcati</name></author><author><name sortKey="Mantelli, B" uniqKey="Mantelli B">B Mantelli</name></author><author><name sortKey="Gabrielli, L" uniqKey="Gabrielli L">L Gabrielli</name></author><author><name sortKey="Lazzarotto, T" uniqKey="Lazzarotto T">T Lazzarotto</name></author><author><name sortKey="Caputo, A" uniqKey="Caputo A">A Caputo</name></author><author><name sortKey="Palu, G" uniqKey="Palu G">G Palu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsagué</name></author><author><name sortKey="Naud, P" uniqKey="Naud P">P Naud</name></author><author><name sortKey="Chow, Sn" uniqKey="Chow S">SN Chow</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Germar, Mj" uniqKey="Germar M">MJ Germar</name></author><author><name sortKey="Lehtinen, M" uniqKey="Lehtinen M">M Lehtinen</name></author><author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J Paavonen</name></author><author><name sortKey="Jaisamrarn, U" uniqKey="Jaisamrarn U">U Jaisamrarn</name></author><author><name sortKey="Garland, Sm" uniqKey="Garland S">SM Garland</name></author><author><name sortKey="Salmeron, J" uniqKey="Salmeron J">J Salmeron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Safaeian, M" uniqKey="Safaeian M">M Safaeian</name></author><author><name sortKey="Porras, C" uniqKey="Porras C">C Porras</name></author><author><name sortKey="Schiffman, M" uniqKey="Schiffman M">M Schiffman</name></author><author><name sortKey="Rodriguez, Ac" uniqKey="Rodriguez A">AC Rodriguez</name></author><author><name sortKey="Wacholder, S" uniqKey="Wacholder S">S Wacholder</name></author><author><name sortKey="Gonzalez, P" uniqKey="Gonzalez P">P Gonzalez</name></author><author><name sortKey="Quint, W" uniqKey="Quint W">W Quint</name></author><author><name sortKey="Van Doorn, Lj" uniqKey="Van Doorn L">LJ van Doorn</name></author><author><name sortKey="Sherman, Me" uniqKey="Sherman M">ME Sherman</name></author><author><name sortKey="Xhenseval, V" uniqKey="Xhenseval V">V Xhenseval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernasconi, Nl" uniqKey="Bernasconi N">NL Bernasconi</name></author><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author><author><name sortKey="Felgner, P" uniqKey="Felgner P">P Felgner</name></author><author><name sortKey="Davies, H" uniqKey="Davies H">H Davies</name></author><author><name sortKey="Glidewell, J" uniqKey="Glidewell J">J Glidewell</name></author><author><name sortKey="Villarreal, L" uniqKey="Villarreal L">L Villarreal</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author><author><name sortKey="Puzone, R" uniqKey="Puzone R">R Puzone</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angelo, Mg" uniqKey="Angelo M">MG Angelo</name></author><author><name sortKey="David, Mp" uniqKey="David M">MP David</name></author><author><name sortKey="Zima, J" uniqKey="Zima J">J Zima</name></author><author><name sortKey="Baril, L" uniqKey="Baril L">L Baril</name></author><author><name sortKey="Dubin, G" uniqKey="Dubin G">G Dubin</name></author><author><name sortKey="Arellano, F" uniqKey="Arellano F">F Arellano</name></author><author><name sortKey="Struyf, F" uniqKey="Struyf F">F Struyf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angelo, Mg" uniqKey="Angelo M">MG Angelo</name></author><author><name sortKey="Zima, J" uniqKey="Zima J">J Zima</name></author><author><name sortKey="Tavares Da, Silva F" uniqKey="Tavares Da "> Silva F Tavares Da</name></author><author><name sortKey="Baril, L" uniqKey="Baril L">L Baril</name></author><author><name sortKey="Arellano, F" uniqKey="Arellano F">F Arellano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Block, Sl" uniqKey="Block S">SL Block</name></author><author><name sortKey="Brown, Dr" uniqKey="Brown D">DR Brown</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author><author><name sortKey="Gold, Ma" uniqKey="Gold M">MA Gold</name></author><author><name sortKey="Sings, Hl" uniqKey="Sings H">HL Sings</name></author><author><name sortKey="Meibohm, A" uniqKey="Meibohm A">A Meibohm</name></author><author><name sortKey="Dana, A" uniqKey="Dana A">A Dana</name></author><author><name sortKey="Haupt, Rm" uniqKey="Haupt R">RM Haupt</name></author><author><name sortKey="Barr, E" uniqKey="Barr E">E Barr</name></author><author><name sortKey="Tamms, Gm" uniqKey="Tamms G">GM Tamms</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcon, N" uniqKey="Garcon N">N Garçon</name></author><author><name sortKey="Chomez, P" uniqKey="Chomez P">P Chomez</name></author><author><name sortKey="Van Mechelen, M" uniqKey="Van Mechelen M">M Van Mechelen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcon, N" uniqKey="Garcon N">N Garçon</name></author><author><name sortKey="Morel, S" uniqKey="Morel S">S Morel</name></author><author><name sortKey="Didierlaurent, A" uniqKey="Didierlaurent A">A Didierlaurent</name></author><author><name sortKey="Descamps, D" uniqKey="Descamps D">D Descamps</name></author><author><name sortKey="Wettendorff, M" uniqKey="Wettendorff M">M Wettendorff</name></author><author><name sortKey="Van Mechelen, M" uniqKey="Van Mechelen M">M Van Mechelen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giannini, Sl" uniqKey="Giannini S">SL Giannini</name></author><author><name sortKey="Hanon, E" uniqKey="Hanon E">E Hanon</name></author><author><name sortKey="Moris, P" uniqKey="Moris P">P Moris</name></author><author><name sortKey="Van Mechelen, M" uniqKey="Van Mechelen M">M Van Mechelen</name></author><author><name sortKey="Morel, S" uniqKey="Morel S">S Morel</name></author><author><name sortKey="Dessy, F" uniqKey="Dessy F">F Dessy</name></author><author><name sortKey="Fourneau, Ma" uniqKey="Fourneau M">MA Fourneau</name></author><author><name sortKey="Colau, B" uniqKey="Colau B">B Colau</name></author><author><name sortKey="Suzich, J" uniqKey="Suzich J">J Suzich</name></author><author><name sortKey="Losonksy, G" uniqKey="Losonksy G">G Losonksy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caulfield, Mj" uniqKey="Caulfield M">MJ Caulfield</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L Shi</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author><author><name sortKey="Tobery, Tw" uniqKey="Tobery T">TW Tobery</name></author><author><name sortKey="Mach, H" uniqKey="Mach H">H Mach</name></author><author><name sortKey="Ahl, Pl" uniqKey="Ahl P">PL Ahl</name></author><author><name sortKey="Cannon, Jl" uniqKey="Cannon J">JL Cannon</name></author><author><name sortKey="Cook, Jc" uniqKey="Cook J">JC Cook</name></author><author><name sortKey="Heinrichs, Jh" uniqKey="Heinrichs J">JH Heinrichs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dessy, Fj" uniqKey="Dessy F">FJ Dessy</name></author><author><name sortKey="Giannini, Sl" uniqKey="Giannini S">SL Giannini</name></author><author><name sortKey="Bougelet, Ca" uniqKey="Bougelet C">CA Bougelet</name></author><author><name sortKey="Kemp, Tj" uniqKey="Kemp T">TJ Kemp</name></author><author><name sortKey="David, Mp" uniqKey="David M">MP David</name></author><author><name sortKey="Poncelet, Sm" uniqKey="Poncelet S">SM Poncelet</name></author><author><name sortKey="Pinto, La" uniqKey="Pinto L">LA Pinto</name></author><author><name sortKey="Wettendorff, Ma" uniqKey="Wettendorff M">MA Wettendorff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robbins, Ha" uniqKey="Robbins H">HA Robbins</name></author><author><name sortKey="Kemp, Tj" uniqKey="Kemp T">TJ Kemp</name></author><author><name sortKey="Porras, C" uniqKey="Porras C">C Porras</name></author><author><name sortKey="Rodriguez, Ac" uniqKey="Rodriguez A">AC Rodriguez</name></author><author><name sortKey="Schiffman, M" uniqKey="Schiffman M">M Schiffman</name></author><author><name sortKey="Wacholder, S" uniqKey="Wacholder S">S Wacholder</name></author><author><name sortKey="Gonzalez, P" uniqKey="Gonzalez P">P Gonzalez</name></author><author><name sortKey="Schiller, J" uniqKey="Schiller J">J Schiller</name></author><author><name sortKey="Lowy, D" uniqKey="Lowy D">D Lowy</name></author><author><name sortKey="Poncelet, S" uniqKey="Poncelet S">S Poncelet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pastrana, Dv" uniqKey="Pastrana D">DV Pastrana</name></author><author><name sortKey="Buck, Cb" uniqKey="Buck C">CB Buck</name></author><author><name sortKey="Pang, Yy" uniqKey="Pang Y">YY Pang</name></author><author><name sortKey="Thompson, Cd" uniqKey="Thompson C">CD Thompson</name></author><author><name sortKey="Castle, Pe" uniqKey="Castle P">PE Castle</name></author><author><name sortKey="Fitzgerald, Pc" uniqKey="Fitzgerald P">PC FitzGerald</name></author><author><name sortKey="Kruger, Ks" uniqKey="Kruger K">KS Kruger</name></author><author><name sortKey="Lowy, Dr" uniqKey="Lowy D">DR Lowy</name></author><author><name sortKey="Schiller, Jt" uniqKey="Schiller J">JT Schiller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crotty, S" uniqKey="Crotty S">S Crotty</name></author><author><name sortKey="Aubert, Rd" uniqKey="Aubert R">RD Aubert</name></author><author><name sortKey="Glidewell, J" uniqKey="Glidewell J">J Glidewell</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Einstein, Mh" uniqKey="Einstein M">MH Einstein</name></author><author><name sortKey="Baron, M" uniqKey="Baron M">M Baron</name></author><author><name sortKey="Levin, Mj" uniqKey="Levin M">MJ Levin</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author><author><name sortKey="Fox, B" uniqKey="Fox B">B Fox</name></author><author><name sortKey="Scholar, S" uniqKey="Scholar S">S Scholar</name></author><author><name sortKey="Rosen, J" uniqKey="Rosen J">J Rosen</name></author><author><name sortKey="Chakhtoura, N" uniqKey="Chakhtoura N">N Chakhtoura</name></author><author><name sortKey="Meric, D" uniqKey="Meric D">D Meric</name></author><author><name sortKey="Dessy, Fj" uniqKey="Dessy F">FJ Dessy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moris, P" uniqKey="Moris P">P Moris</name></author><author><name sortKey="Van Der Most, R" uniqKey="Van Der Most R">R van der Most</name></author><author><name sortKey="Leroux Roels, I" uniqKey="Leroux Roels I">I Leroux-Roels</name></author><author><name sortKey="Clement, F" uniqKey="Clement F">F Clement</name></author><author><name sortKey="Drame, M" uniqKey="Drame M">M Drame</name></author><author><name sortKey="Hanon, E" uniqKey="Hanon E">E Hanon</name></author><author><name sortKey="Leroux Roels, Gg" uniqKey="Leroux Roels G">GG Leroux-Roels</name></author><author><name sortKey="Van, Mechelen M" uniqKey="Van M">Mechelen M Van</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horton, H" uniqKey="Horton H">H Horton</name></author><author><name sortKey="Thomas, Ep" uniqKey="Thomas E">EP Thomas</name></author><author><name sortKey="Stucky, Ja" uniqKey="Stucky J">JA Stucky</name></author><author><name sortKey="Frank, I" uniqKey="Frank I">I Frank</name></author><author><name sortKey="Moodie, Z" uniqKey="Moodie Z">Z Moodie</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Chiu, Yl" uniqKey="Chiu Y">YL Chiu</name></author><author><name sortKey="Mcelrath, Mj" uniqKey="Mcelrath M">MJ McElrath</name></author><author><name sortKey="De Rosa, Sc" uniqKey="De Rosa S">SC De Rosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chattopadhyay, Pk" uniqKey="Chattopadhyay P">PK Chattopadhyay</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Roederer, M" uniqKey="Roederer M">M Roederer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frentsch, M" uniqKey="Frentsch M">M Frentsch</name></author><author><name sortKey="Arbach, O" uniqKey="Arbach O">O Arbach</name></author><author><name sortKey="Kirchhoff, D" uniqKey="Kirchhoff D">D Kirchhoff</name></author><author><name sortKey="Moewes, B" uniqKey="Moewes B">B Moewes</name></author><author><name sortKey="Worm, M" uniqKey="Worm M">M Worm</name></author><author><name sortKey="Rothe, M" uniqKey="Rothe M">M Rothe</name></author><author><name sortKey="Scheffold, A" uniqKey="Scheffold A">A Scheffold</name></author><author><name sortKey="Thiel, A" uniqKey="Thiel A">A Thiel</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Hong Kong</li><li>Inde</li><li>Singapour</li><li>Suède</li></country></list><tree><country name="Hong Kong"><noRegion><name sortKey="Leung, Ting Fan" sort="Leung, Ting Fan" uniqKey="Leung T" first="Ting Fan" last="Leung">Ting Fan Leung</name></noRegion><name sortKey="Liu, Anthony Pak Yin" sort="Liu, Anthony Pak Yin" uniqKey="Liu A" first="Anthony Pak-Yin" last="Liu">Anthony Pak-Yin Liu</name></country><country name="Singapour"><noRegion><name sortKey="Lim, Fong Seng" sort="Lim, Fong Seng" uniqKey="Lim F" first="Fong Seng" last="Lim">Fong Seng Lim</name></noRegion><name sortKey="Lee, Bee Wah" sort="Lee, Bee Wah" uniqKey="Lee B" first="Bee Wah" last="Lee">Bee Wah Lee</name><name sortKey="Oh, Helen May Lin" sort="Oh, Helen May Lin" uniqKey="Oh H" first="Helen May Lin" last="Oh">Helen May Lin Oh</name><name sortKey="Tan, Ngiap Chuan" sort="Tan, Ngiap Chuan" uniqKey="Tan N" first="Ngiap Chuan" last="Tan">Ngiap Chuan Tan</name></country><country name="France"><noRegion><name sortKey="Thollot, Franck" sort="Thollot, Franck" uniqKey="Thollot F" first="Franck" last="Thollot">Franck Thollot</name></noRegion><name sortKey="Rouzier, Roman" sort="Rouzier, Roman" uniqKey="Rouzier R" first="Roman" last="Rouzier">Roman Rouzier</name></country><country name="Suède"><noRegion><name sortKey="Rombo, Lars" sort="Rombo, Lars" uniqKey="Rombo L" first="Lars" last="Rombo">Lars Rombo</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Friel, Damien" sort="Friel, Damien" uniqKey="Friel D" first="Damien" last="Friel">Damien Friel</name></noRegion><name sortKey="De Muynck, Benoit" sort="De Muynck, Benoit" uniqKey="De Muynck B" first="Benoit" last="De Muynck">Benoit De Muynck</name><name sortKey="De Simoni, Stephanie" sort="De Simoni, Stephanie" uniqKey="De Simoni S" first="Stéphanie" last="De Simoni">Stéphanie De Simoni</name><name sortKey="Folschweiller, Nicolas" sort="Folschweiller, Nicolas" uniqKey="Folschweiller N" first="Nicolas" last="Folschweiller">Nicolas Folschweiller</name><name sortKey="Hezareh, Marjan" sort="Hezareh, Marjan" uniqKey="Hezareh M" first="Marjan" last="Hezareh">Marjan Hezareh</name><name sortKey="Struyf, Frank" sort="Struyf, Frank" uniqKey="Struyf F" first="Frank" last="Struyf">Frank Struyf</name><name sortKey="Thomas, Florence" sort="Thomas, Florence" uniqKey="Thomas F" first="Florence" last="Thomas">Florence Thomas</name></country><country name="Inde"><noRegion><name sortKey="Suryakiran, Pemmaraju" sort="Suryakiran, Pemmaraju" uniqKey="Suryakiran P" first="Pemmaraju" last="Suryakiran">Pemmaraju Suryakiran</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000191 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000191 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4514190
|texte= Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26062002" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |